Here's a podcast that I recorded with my buddy DaveO last summer. You probably know that I prefer lighter games. Well, DaveO likes the heavier stuff (as well as some quicker games). We got to talking about that, and the conversation drifted to our differences in opinion about the number of players in a game. I felt that five was a troublesome number, while he could quickly think of several games that he strongly preferred with five. Me? I'd suggest splitting into a 2 and 3-player pair of games, but most wouldn't agree with that!
We talk about some 5-player classics like El Grande and Mu, but also drift toward a disagreement about playing Web of Power with that number. Add in Medici, Die Macher, Agricola, Age of Steam, and others to round out the discussion.